Dose range
3 → 14 mg/day
Route
Oral tablet, daily, fasted with 4 oz water
Indication(s)
Type 2 diabetes (only)

Titration schedule

StepDoseDurationNotes
13 mg/day30 daysStarter; not for glycemic control
27 mg/day30+ daysMaintenance option
314 mg/dayMaxIf inadequate response at 7 mg

Important notes

  • This FDA-approved drug dosing chart is intended as a reference for clinicians and patients reviewing protocols, not a substitute for individualized prescriber guidance.
  • FDA-approved label dosing.
  • Compounded versions, where applicable, must be prepared by a licensed 503A or 503B compounding pharmacy. FDA has warned compounders that used salt forms (semaglutide sodium and semaglutide acetate), which are not the active ingredient in any approved drug.

References

  1. Rybelsus (oral semaglutide) prescribing information / clinical literature.
  2. FDA, bulk drug substances used in compounding under section 503A (interim categories), accessed October 2026.
  3. USP <797>: Pharmaceutical Compounding — Sterile Preparations.