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Guide · Updated October 16, 2026

Semaglutide Dosing Schedule

Wegovy: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg weekly. Ozempic: 0.25 → 0.5 → 1.0 → 2.0 mg weekly. Rybelsus: 3 → 7 → 14 mg daily oral.

EducationalUpdated October 16, 2026
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Editorial team
Dr. Sam Saberian · Lead Medical Researcher
Medical review by Alen A. Schwartz, MD · Edited by Julliana Edwards · Last updated October 16, 2026

Overview

Wegovy: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg weekly. Ozempic: 0.25 → 0.5 → 1.0 → 2.0 mg weekly. Rybelsus: 3 → 7 → 14 mg daily oral.

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Questions readers ask

How long does each Wegovy dose step last?

Wegovy rises from 0.25 to 0.5, 1.0, 1.7 and then 2.4 mg weekly, with about four weeks at each step. The 0.25 mg dose is a starting and tolerability dose only and is not meant as a maintenance dose.

How does the Ozempic schedule differ from Wegovy?

Ozempic steps through 0.25, 0.5 and 1.0 mg weekly and tops out at 2.0 mg, while Wegovy continues to 1.7 mg and a 2.4 mg maintenance dose. Rybelsus is an oral tablet taken daily at 3, then 7, then 14 mg.

Does compounded semaglutide cost more as the dose rises?

That depends on the provider. NexLife charges the same price at every dose, $119 a month on a 12-month plan charged monthly or $139 month to month (read October 14, 2026), so stepping up to 2.4 mg does not change the monthly bill.

What weight loss is seen at the 2.4 mg maintenance dose?

In the STEP 1 trial, semaglutide 2.4 mg once weekly produced a mean weight loss of 14.9% at 68 weeks using the treatment-policy estimand. Your prescribing clinician sets the pace of titration based on how well you tolerate each step.

Primary sources

  1. FDA: Concerns with unapproved GLP-1 drugs used for weight loss (current as of October 1, 2026)
  2. FDA: Policies for compounders as GLP-1 supply stabilizes (updated April 1, 2026)
  3. FDA: Compounding and the FDA — questions and answers
  4. FDA: Registered outsourcing facilities (503B)
  5. Wilding JPH et al. Once-weekly semaglutide in adults with overweight or obesity (STEP 1). N Engl J Med 2021
  6. Wegovy (semaglutide) prescribing information, Novo Nordisk